Electric Literature of 13078-80-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13078-80-3, name is 2-(2-Chlorophenyl)ethanamine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Propyl N-cyano-6-amino-3-pyridinecarboximidate (200 mg, 0.98 mmol) and 2-(2-chlorophenyl)ethylamine (170 mg, 1.09 mmol) were dissolved in a mixture of methanol (10 ml) and DMF (1.5 ml), and the mixture was stirred at room temperature for 2.5 hours. The reaction mixture was concentrated under reduced pressure and subjected to silica gel column chromatography (Wako Gel C-200, 25 g), and elution was conducted with chloroform:methanol (30:1) to give the title compound (250 mg, yield 85%) as colorless powder. Mp 222 C. IR (KBr) cm-1:3220, 2160, 1570, 740. 1 H-NMR (90 MHz, DMSO): delta (ppm) 8.91(1Hr brs, NH), 8.13(1H, d, J=2.5Hz, H-6), 7.60(1H, dd, J=2.5, 8.6Hz, H-4), 7.45-7.2(4H, C6 H4 Cl), 6.60(2H, brs, NH2), 6.48(1H, d, J=8.6Hz, H-3), 3.56(2H, m, NHCH2 CH2 C6 H4 Cl), 3.02(2H, t, J=7.0Hz, NHCH2 CH2 C6 H4 Cl).
The synthetic route of 2-(2-Chlorophenyl)ethanamine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kirin Beer Kabushiki Kaisha; US5508293; (1996); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics