Application of 626-43-7, A common heterocyclic compound, 626-43-7, name is 3,5-Dichloroaniline, molecular formula is C6H5Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a reaction flask, 48 g (0.3 mol) of 3,5-dichloroaniline was added to a mixed solution of 500 mL of water and 500 mL of hydrochloric acid.Medium, after stirring evenly, cool down to 0 C,Under stirring, 400 mL of an aqueous solution containing 23 g (0.34 mol) of sodium nitrite was added dropwise, and after mixing, the mixture was uniformly mixed to obtain a solution A;1000 mL of an aqueous solution containing 67 g (1.2 mol) of potassium hydroxide was placed in another reaction flask.Under the condition of 0 C, slowly add 250 mL of ethanol (35 mol) dissolved in ethyl pyruvate, and then add to the solution B after stirring.After the solution A was brought to a temperature of 0 C, the solution B was slowly added dropwise to the solution A, and after the completion of the dropwise addition, the temperature was raised to 40 C for 10 minutes, and then the reaction solution was extracted three times with 1000 mL of diethyl ether.The organic phases were combined, dried over anhydrous magnesium sulfate (100 g), concentrated, and then recrystallized from a mixture of n-hexane and acetone (V-hexane: Vacetone = 2:1) to give ethyl-2-(2-(3,5-) Chlorophenyl)indenyl)propionic acid 78g,Yield is 95%
The synthetic route of 626-43-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Henan Wanliu Biological Technology Co., Ltd.; Yang Weixiao; Ren Baoqi; Wang Jiahao; (13 pag.)CN108864089; (2018); A;,
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