Electric Literature of 83121-15-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 83121-15-7, name is 3,5-Dichloro-2,4-difluoroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
2.7 mmol of 2,4-difluoro-3,5-dichloro-aniline, and 20 ml of 1,2-dichloroethane in a 100 ml round bottom flask and stirred until the 2,4-difluoro-3,5diclofenac was completely dissolved, was added dropwise with stirring 3 mmol of 4-methyl-1,2,3-thiadiazole-5-formylphenyl isocyanate, dropwise over 15 minutes immediatelythereafter precipitation, followed by stirring at room temperature for 8 hours aftercompletion of the reaction, allowed to stand, the solid product was suction filtered,the filtrate solvent was removed by rotary evaporation, ethyl acetate with a volumeratio of 1:3: recrystallized from petroleum ether after the refrigerator to precipitatea solid, the solid product was combined with 1:3 volume ratio of ethyl acetate:petroleum ether, washed and dried to obtain the product; mp: 187-189 C, yield 92%;
The synthetic route of 3,5-Dichloro-2,4-difluoroaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Lier Chemical co Limited; Nankai University; Fan, ZhiJin; Guo, dandan; fan, Qian; Yang, Wei Qing; Fu, yifeng; Zhao, Hui; Wang, Shouxin; Wang, huan; Mi, Na; (37 pag.)CN102225918; (2016); B;,
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