Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56961-77-4, name is 1-Bromo-2,3-dichlorobenzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Bromo-2,3-dichlorobenzene
Intermediate 40:[0172] A well-dried flask was first charged with l-bromo-2,3-dichlorobenzene (10 g, 44 mmol) and piperazine (4.55 g, 53 mmol), which was evacuated and backfilled with N2 through a balloon under gentle warming (40C). Toluene was charged and the mixture was bubbled with N2 for 10 min, then BINAP (822 mg, 1.32 mmol) and Pd2dba3 (403 mg, 0.44 mmol) were added to the mixture. After the addition of DBU (8.0 mL), the solution was warmed at 60-70C while a fine powder of ffluONa (7.39 g, 66 mmol) was added in one portion to start the amination. After the reaction mixture cooled to rt, (Boc)20 (24 g, 110 mmol) was dissolved in DCM and added dropwise to the reaction mixture, then stirred at rt for 3 h. The reaction mixture was diluted with water and extracted with EtOAc. The combined EtOAc layers were washed with brine, dried over anhydrous Na2S04, concentrated in vacuo and purified by flash chromatography on silica gel column (elution with PE/EtOAc = 10:1) to give tert-butyl 4-(2,3-dichlorophenyl)piperazine-l- carboxylate (intermediate 40) (11.1 g, 76%) as a white solid.
The synthetic route of 56961-77-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; JIN, Jian; ROTH, Bryan; FRYE, Stephen; WO2012/3418; (2012); A2;,
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