Electric Literature of 174913-12-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 174913-12-3 name is 1-Bromo-3-chloro-5-methoxybenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 2: 1 -Bromo-2,3-dichloro-5-methoxybenzene. To a solution of 1 -bromo-3-chloro-5-methoxybenzene (300 mg, 1 .35 mmol, 1 equiv.) in DMF (5 ml_) was added trichloro-1 ,3,5-triazinane-2,4,6-trione (1 15 mg, 0.49 mmol, 0.36 equiv.) and the reaction was stirred at 50 C for 3 h. The reaction mixture was concentrated and the crude product was purified by column chromatography (Heptane/EtOAc 100 %? 20: 1) to afford the desired product as a white solid (253 mg, 73 %). LCMS [M+H]+ 254; 1 H NMR (400 MHz, CD3CI) delta 7.09 (1 H, d, J = 3.0 Hz), 6.97 (1 H, d, J = 3.0 Hz), 3.77 (3H , s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-3-chloro-5-methoxybenzene, and friends who are interested can also refer to it.
Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; WALLNER, Olov; KOOLMEISTER, Tobias; VALLIN, Karl Sven Axel; HENRIKSSON, Carl Martin; HOMAN, Evert; HELLEDAY, Thomas; JACQUES, Sylvain; DESROSES, Matthieu; JACQUES-CORDONNIER, Marie-Caroline; FISKESUND, Roland Julius Yu; (359 pag.)WO2015/187089; (2015); A1;,
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