Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 623-12-1, name is 1-Chloro-4-methoxybenzene, A new synthetic method of this compound is introduced below., Safety of 1-Chloro-4-methoxybenzene
General procedure: Palladacycle C1 (0.005mmol), olefin (0.75mmol), aryl chloride (0.5mmol), K2CO3 (1.0mmol) and DMF/H2O (2ml, 1:1) were added to a small tube and the mixture was heated to 110C for 6h in the presence of air. The reactions were monitored by thin-layer chromatography (TLC). At the end of the cross-coupling reactions, the mixture was cooled, extracted with n-hexane:EtOAc (8:2), filtered and purified by recrystallization from ethanol and water or purified by silica gel column chromatography (n-hexane:EtOAc, 8:2).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Javad Sabounchei, Seyyed; Hashemi, Ali; Yousefi, Abed; Gohari Derakhshandeh, Parviz; Karamian, Roya; Asadbegy, Mostafa; Van Hecke, Kristof; Polyhedron; vol. 135; (2017); p. 1 – 9;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics