32768-54-0, name is 2,3-Dichlorotoluene, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C7H6Cl2
Example 1: Synthesis of 2,3-dichlorobenzotrichloride; A UV photochlorination reactor was loaded with 245 g of 2,3-dichlorotoluene (1.52 moles) and 1225 g of CCl4. The reactor was heated to 75 0C and chlorine was introduced at a flow of 190 g/h. At the end of the reaction, the flow is decreased to minimize break-through of chlorine. The crude mixture was analyzed showing a content of 2,3-dichlorobenzal chloride < 0.2 %. The solvent CCl4 was distilled from the reaction mixture at 600 to 800 mbar. The crude product was then let to distil at 13 mbar and 128 0C giving 334.2 g of 2,3- dichlorobenzotrichloride with a GC assay of 98.2 %. Yield was 81.6 %.; Example 3: Synthesis of 2,3-dichlorobenzotrichloride; A UV photochlorination reactor was loaded with 220.5 g of 2,3-dichlorotoluene (1.37 moles) and 1584 g of CCl4. The reactor was heated to 75 0C and chlorine was introduced at a flow of 190 g/h. At the end of the reaction, the flow was decreased to minimize break-through of chlorine. The crude mixture was analyzed showing a content of 2,3-dichlorobenzal chloride < 0.2 %. The solvent was distilled from the reaction mixture (1808 g) giving 1351 g of CCl4. The crude 2,3-dichlorobenzotrichloride (366.5 g) had a GC assay of 96.0 %. Yield was 97.1%.; Example 5: Synthesis of 2,3-dichlorobenzotrichloride; A UV photochlorination reactor was loaded with 1042 g of 2,3-dichlorotoluene (6.47 moles). The reactor was heated to 100 0C and chlorine was introduced at a flow of 370 g/h. At the end of the reaction, the flow was decreased to 40 g/h to minimize break-through of chlorine. The crude mixture was analysed showing a content of 2,3-dichlorobenzal chloride of 0.3 %. The 2,3-dichlorobenzotrichloride (1675.5 g) was obtained with a GC assay of 97.2 %. Yield was 95.2 %.
The synthetic route of 32768-54-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CALAIRE CHIMIE SAS; WO2007/138075; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics