The synthetic route of 15205-11-5 has been constantly updated, and we look forward to future research findings.
Synthetic Route of 15205-11-5,Some common heterocyclic compound, 15205-11-5, name is 2-Chloro-4-fluorobenzylamine, molecular formula is C7H7ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 173; lambda/-[(2-chloro-4-fluorophenyl)methyl]-2-[1-(2-hydroxyethyl)-5- (trifluoromethyl)-1 H-pyrazol-4-yl]acetamide (E173) Crude [1-(2-hydroxyethyl)-5-(trifluoromethyl)-1 H-pyrazol-4-yl]acetic acid (6.0 g, -6.52 mmol, prepared as described below) was suspended in dimethylformamide (8 ml) and to this was added water soluble carbodiimide (1.5 g, 7.82 mmol), 1- hydroxybenzotriazole (1.06 g, 7.82 mmol), N-ethyl morpholine (2.49 ml, 19.56 mmol), and [(2-chloro-4-fluorophenyl)methyl]amine (1.25 g, 7.82 mmol). The mixture was stirred at room temperature overnight and then partitioned between ethyl acetate (50 ml) and water (50 ml). The organic phase was separated and washed with more water (2 x 20 ml), dried over anhydrous sodium sulphate, filtered, and concentrated to an orange oil. This material was purified by automated flash-silica column chromatography (Biotage SP4), eluting with 0-100% ethyl acetate in hexane, to give lambda/-[(2-chloro-4-fluorophenyl)methyl]-2-[1-(2-hydroxyethyl)-5-(trifluoromethyl)-1 H- pyrazol-4-yl]acetamide as a sticky white solid (~1 g). LC/MS [M+H]+ = 381 , retention time = 2.47 minutes.
The synthetic route of 15205-11-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2008/138876; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics