Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19752-55-7, name is 1-Bromo-3,5-dichlorobenzene, A new synthetic method of this compound is introduced below., SDS of cas: 19752-55-7
3,5-dichlorobromobenzene (2.3 g, 10 mmol), 9-phenylcarbazole-3-boronic acid (2.5 g, 11 mmol) Sodium carbonate (5.1 g, 48 mmol), Pd2 (dba) 3 (0.4 g, 0.4 mmo 1), Toluene, ethanol, water 50ml in turn added to the reaction bottle, The reaction was refluxed under nitrogen for 10 hours, Cooled to room temperature, separated, and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, washed with saturated brine and water respectively. The organic layer was dried over magnesium sulfate, filtered, The column was silica gel to give 3.0 g of product, HPLC purity 99.2percent.
The synthetic route of 19752-55-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CECEP Wanrun Co., Ltd.; Li Chong; Yu Kaichao; Zhang Zhaochao; (42 pag.)CN107098918; (2017); A;,
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