Reference of 4090-55-5, These common heterocyclic compound, 4090-55-5, name is 2-Chloro-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 250 ml three-necked flask equipped with a stirrer, a thermometer and a reflux condenser, 50 ml of acetonitrile, 2-aminothiazole (0.11 mol, 11.0 g) and triethylamine (0.3 mol, 30.3 g) were added and stirred to mix well. Further, a solution of neopentyl glycolphosphoryl chloride (0.1 mol, 18.5 g) in acetonitrile (100 ml) was added dropwise with stirring at 3 C, and the system remains clear and transparent. After the solution was added dropwise, the system was allowed to react at 3 C for 3 h, and then heated to 70 C for 8 h. After completion of the reaction, the solvent was removed by rotary evaporation to obtain a reddish brown solid, which was washed three times with chloroform to remove the triethylamine hydrochloride. After drying, a one-component intumescent flame retardant (PAZ) for epoxy resin was obtained. The yield was 95%.
Statistics shows that 2-Chloro-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide is playing an increasingly important role. we look forward to future research findings about 4090-55-5.
Reference:
Patent; Fujian Normal University; Jian Rongkun; Ai Yuanfang; Xia Long; Pang Fuqu; (9 pag.)CN109400649; (2019); A;,
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