Related Products of 89794-02-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89794-02-5 name is 4-Bromo-2-chlorotoluene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
l-(3-Chloro-4-methylphenyl)-3-phenylpiperazine (compound of type 14, Figure 11): 2-phenyl- piperazine (0.13 g, 0.80 mmol), 2-Cl-4-Br-toluene (0.10 ml, 0.76 mmol), Pd2dba3 (0.07 g, 0.08 mmol), BINAP (0.048 g, 0.08 mmol) and OtBu (0.13 g, 1.14 mmol) were stirred in toluene (2 mL) at 80C. Aqueous work up, dichloromethane extraction and removal of volatiles was followed by flash chromatography separation using ethyl acetate gradient ( 10-60%) in hexanes to afford 0.13 g (56%) of l-(3–Chloro-4-methylphenyl)-3 -phenylpiperazine 14. 1H – NMR (CDC13, 400 MHz, delta ppm) 7.46-7.44 (m, 2H), 7.39-7.29 (m, 3H), 7.08 (d, / = 8.4 Hz, 1H), 6.91 (d, / = 2.8 Hz, 1H), 6.75 (dd, / = 8.8, 2.8 Hz, 1H), 3.96 (dd, / = 10.4, 2.8 Hz, 1H), 3.57-3.54 (m, 2H), 3.24 (dt, / = 11.6, 3.2 Hz, 1H), 2.86 (td, / = 11.6, 3.2 Hz, 1H), 2.68 (t, / = 11.2 Hz, 1H), 2.27 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2-chlorotoluene, and friends who are interested can also refer to it.
Reference:
Patent; SHIFA BIOMEDICAL CORPORATION; ABDEL-MEGUID, Sherin, Salaheldin; ABOU-GHARBIA, Magid; BLASS, Benjamin; CHILDERS, Wayne; ELSHOURBAGY, Nabil; GHIDU, Victor; MARTINEZ, Rogelio; MEYERS, Harold; MOUSA, Shaker, A.; WO2014/150395; (2014); A1;,
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