Adding a certain compound to certain chemical reactions, such as: 627-42-9, name is 2-Methoxyethyl chloride, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-42-9, Recommanded Product: 627-42-9
Example 23. 3-[4-tert-Butyl-2-(2-methoxy-ethoxy)-phenyl]-N-(3-fluoro-4- methanesulfonylamino-5-vinyl-benzyl)-acrylamideStep 1 : 4-tert-Butyl-1-iodo-2-(2-methoxyethoxy)benzeneNaH (21.0mg, 0.5250mmol, 60% disp.oil , 5eq) and tert-Butyl-2-iodo-phenol (29.0 mg, 0.105 mmol, 1eq) were added DMF. Chloroethyl methyl ether (23.96^, 0.26mmol, 2.5eq) was added into the mixture. The reaction mixture was stirred overnight at 90 C. The reaction mixture was quenched by adding H2O. After DMF was removed in vacuo, the residue was extracted with EtOAc. A combined organic layer was washed by H2O and brine, dried with Na2SO4, and then concentrated in vacuo. The residue was purified with column chromatography (n-Hexane :EtOAc = 20:1 ) to give liquid (32.0mg, 91.2%).1H NMR (400MHz, CDCI3) : delta 7.58(d, J=8.4Hz, 1H), 6.82(d, J=2.0Hz, 1H), 6.69(dd, J=8.4, 2.4Hz, 1H), 4.10(t, J=4.8Hz, 2H), 3.75(dd, J=4.8, 4.4Hz, 2H), 3.43(s, 3H), 1.22(s, EPO
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Methoxyethyl chloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AMOREPACIFIC CORPORATION; WO2006/101318; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics