Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6940-78-9, name is 1-Bromo-4-chlorobutane, A new synthetic method of this compound is introduced below., Safety of 1-Bromo-4-chlorobutane
General procedure: K2C03 (1.0 eq.) and the dihaloalkane (XIII, 1.0 eq.) were added to a solution of the appropriatethio-derivative XIV (1.0 eq.) in DMF (0.5 mL per mmcl XIII). The reaction mixture was stirred under nitrogen atmosphere for 5 h at rt. The crude reaction mixture was filtered and concentrated under reduced pressure. Sat. aq. NaHCO3 solution (1.0 mL per mmol XIII) was added and the mixture extracted with Et20 (3 x 1.0 mL per mmol XIII). The combined organic layers were evaporated on silica. Pure compound XV was obtained by column chromatography using theTeledyne ISCO apparatus (cyclohexane:EtOAc). The title compound was obtained according to the General Procedure VIII (Step 1) starting from1-bromo-4-chlorobutane (8.57 g, 50.0 mmol) and thiophenol (5.51 g, 50.0 mmol). Colorless liquid(8.06 g, 80%). 1H NMR (400 MHz, CDCI,) 6 1.79 – 1.88 (m, 2H), 1.91 – 1.99 (m, 2H), 2.98 (t, i = 7.1Hz, 2H), 3.57 (t, J = 6.5 Hz, 2H), 7.17 – 7.24 (m, 1H), 7.28 – 7.34 (m, 2H), 7.35 – 7.39 (m, 2H). MS(ESI) m/z: non-ionizable compound under routine conditions used.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; UNIVERSITA’ DEGLI STUDI DI PARMA; PIOMELLI, Daniele; PIZZIRANI, Daniela; BACH, Anders; SCARPELLI, Rita; MELZIG, Laurin; MOR, Marco; (72 pag.)WO2015/173169; (2015); A1;,
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