In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10061-02-6 as follows. SDS of cas: 10061-02-6
Example 15: N-((S)-2-Amino-l-hydroxycarbamoyl-2-methyl-propyl)-4-((E)-7-hydroxy- hept-2-en-4-ynyIoxy)-benzamide (Compound 15); 15Step 15-A:To a solution of trans- 1,3 -dichloropropene (2.19 g, 19.7 mmol), potassium carbonate (3.63 g, 26.3 mmol), and potassium iodide (0.109 g, 0.657 mmol) in acetonitrile (200 mL) was added methyl-4-hydroxybenzoate (2.0 g, 13.2 mmol). The reaction was stirred at 80 0C for 4 hr after which it is quenched with brine, extracted with ethyl acetate, and washed with water. Organic phase dried with anhydrous magnesium sulfate, filtered, concentrated followed by purification with silica-gel chromatography (0-50% Ethyl Acetate/Heptane) to afford 15b (2.77 g). Found m/z ES+ = 227.
According to the analysis of related databases, 10061-02-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; DOBLER, Markus, Rolf; LENOIR, Francois; PARKER, David, Thomas; PENG, Yunshan; PIIZZI, Grazia; WATTANASIN, Sompong; WO2010/31750; (2010); A1;,
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