Adding a certain compound to certain chemical reactions, such as: 13745-86-3, name is 11-Chlorodibenzo[b,f][1,4]thiazepine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13745-86-3, category: chlorides-buliding-blocks
Combine 11-chloro-dibenzo[b,f][1, 4] thiazepine (700 mg), 2- (R)-BENZYL-PIPERAZINE (1.0 g) and toluene (10 mL), heat to reflux for 19 hours, then cool down to ambient temperature. Concentrate and purify by flash chromatography (dichloromethane then gradient of methanol 3-10%) to give the title compound as a white solid (734 mg, 74%): mp 56-69 C ; LHNMR (CDCI3) O2. 58 (dd, 1H), 3.18-2. 60 (M, 6H), 6.88 (dt, 1H), 7.07 (dd, 1H), 7.34-7. 14 (m, 9H), 7.39 (dd, 1H), 7.53-7. 47 (m, 1H) ; MS (APCI) N7LZ (rel intensity) 386.4 (100).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 11-Chlorodibenzo[b,f][1,4]thiazepine, and friends who are interested can also refer to it.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/26177; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics