In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 886762-39-6, name is 3,4-Dichloro-2-fluoroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 3,4-Dichloro-2-fluoroaniline
1 .43 g of the compound obtained in (1-5), 1 .91 g of (R)-(-)-N-Boc-4- hydroxypiperidine and 1 .96 g of triphenylphosphine were added to 20 ml of methylene chloride, and 2.01 ml of diisopropylazodicarboxylate was added thereto dropwise. The resulting mixture was stirred at room temperature for 1 hour and distilled under a reduced pressure, and the residue was briefly purified by columnchromatography (ethylacetate : methylenechloride : methanol = 20 :20: 1). The partially purified residue was then dissolved in 60 ml of 2-propanol, 1 .17 g of 3,4- dichloro-4-fluoroaniline was thereto, and the mixture was stirred at 1 00 00 for 3 hours. The resulting mixture was distilled under a reduced pressure to remove the solvent, and the residue was dissolved in 60 ml of methylenechloride. 60 ml oftrifluoroacetic acid was added thereto and the mixture was stirred at room temperature for 1 hour. The resulting mixture was distilled under a reduced pressure to remove the solvent. Saturated sodium bicarbonate solution was added to the resulting residue to make it basic, followed by extraction with chloroform. The organic layer was dried over anhydrous sodium sulfate, filtered, and distilled under a reduced pressure. The resulting residue was subjected to column chromatography (chloroform : methanol = 1: 2) to obtain the title compound.
The synthetic route of 886762-39-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SPECTRUM PHARMACEUTICALS, INC.; CHATURVEDUAL, Prasad, V.; KOLLI, Prasad; (46 pag.)WO2019/79599; (2019); A1;,
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