In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 108-41-8, name is 1-Chloro-3-methylbenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: chlorides-buliding-blocks
General procedure: In the test tube were placed 7% Pd/WA30 (19.0 mg, 12.5 mumol), the aryl chloride (250 mumol), the arylboronic acid (375 mumol), Cs2CO3 (163 mg, 500 mumol), and DMA (1 mL). The mixture was stirred at 80 C under an Ar atmosphere. The reaction progress was monitored by TLC analysis (hexane-EtOAc, 5:1). When the reaction was completed within 24 h, the mixture was cooled to r.t., diluted with Et2O (5 mL), and passed through a cotton filter. The catalyst on the filter was washed with Et2O (2 × 15 mL) and H2O (3 × 10 mL). The combined filtrate was separated into two layers. The aqueous layer was extracted with Et2O (20 mL), and the combined organic layers were washed with H2O (4 × 20 mL) and brine (20 mL), dried over Na2SO4, filtered, and concentrated in vacuo. To the residue was added CDCl3 (ca. 1 mL) and 1,4-dioxane (8.53 muL, 100 mumol). After the determination of the reaction yield by 1H NMR, the product was purified by silicagel column chlomatography using hexane-EtOAc (10:1) as eluents to give the corresponding biaryl. When the reaction was incomplete after 24 h, the reaction mixture was treated in the same manner as described above.
The synthetic route of 108-41-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Monguchi, Yasunari; Ichikawa, Tomohiro; Netsu, Moeko; Hattori, Tomohiro; Mizusaki, Tomoteru; Sawama, Yoshinari; Sajiki, Hironao; Synlett; vol. 26; 14; (2015); p. 2014 – 2018;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics