Some common heterocyclic compound, 870-24-6, name is 2-Chloroethanamine hydrochloride, molecular formula is C2H7Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-Chloroethanamine hydrochloride
In a round-bottomed flask, 2-chloroethylamine hydrochloride (2 g, 17.0 mmol) and Et3N (2.37 mL, 11.0 mmol) were dissolved in anhydrous CH2Cl2 (24 mL). Boc2O (3.6 mL, 15.3 mmol) was added to the resulting solution under N2 at 0 C. The reaction mixture was stirredat r.t. for 4 h. The mixture was then washed with H2O and brine, dried (Na2SO4), filtered, and concentrated under reduced pressure to give the title product as a dark liquid; yield: 2.91 g (16.21 mmol, 99%), which was used directly in the next synthetic step. IR (neat): 3347, 2924, 2854, 2361, 2342, 1725, 1709, 1503, 1462 cm-1. 1H NMR (400 MHz, CDCl3): delta = 1.18 [s, 9 H, C(CH3)3], 3.36-3.48 (m, 2H, CH2NH), 3.49-3.63 (m, 2 H, ClCH2), 4.93 (br s, 1 H, NHCO). 13C NMR (100 MHz, CDCl3): delta = 28.2 [C(CH3)3], 32.8 (CH2NH), 45.7 (CH2Cl), 79.8 [C(CH3)3], 155.8 (C=O). Anal. Calcd for C7H14ClNO2: C, 46.80; H, 7.86; N, 7.80. Found: C, 46.91; H, 7.89; N, 7.74.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 870-24-6, its application will become more common.
Reference:
Article; Manasieva, Leda Ivanova; Maria, Battisti Umberto; Prandi, Adolfo; Brasili, Livio; Franchini, Silvia; Synthesis; vol. 47; 23; (2015); p. 3767 – 3775;,
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