In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 933190-51-3 as follows. Safety of 8-Bromo-6-chloroimidazo[1,2-b]pyridazine
Compound 3-1 (0 · 27g, lmmol), morpholine 0 · 12g (l. 2mmol) and triethylamine (0 · 3ml, 2. 2mmol) Was added to 5ml of tetrahydrofuran was refluxed for 12h, after completion of the reaction, washed with water, extracted with dichloromethane, washed with saturated brine, dried over anhydrous sodium sulfate. Petroleum ether: ethyl acetate 6: 1 column chromatography to obtain a solid, yield 80%
According to the analysis of related databases, 933190-51-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Peking University; Zhang Liangren; (50 pag.)CN103360399; (2016); B;,
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