In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 622-86-6 as follows. Safety of (2-Chloroethoxy)benzene
a. Diethyl 2,2-di(2-phenoxyethyl)malonate To a stirred solution of sodium (2.3 g) in absolute EtOH (50 ml) was added diethyl malonate (15.2 ml) followed by 2-phenoxyethyl chloride (15. 7 g). The reaction mixture was then refluxed for 12 hr. The EtOH was evaporated under vacuum and the mixture diluted with water (40 ml). The aqueous phase was extracted with Et2 O. The combined Et2 O extracts were washed (brine), dried (MgSO4) filtered and evaporated. Bulb to bulb distillation afforded 12.2 g (27%) of the title diester as a clear liquid, bp 155-175 (106 Pascals, 0.8 Torr); TLC, Rf =0.34, CH2 Cl2.
According to the analysis of related databases, 622-86-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ICI Americas Inc.; US4910190; (1990); A;,
Chloride – Wikipedia,
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