In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4152-90-3 as follows. SDS of cas: 4152-90-3
General procedure: The mixture of benzylamine 1a (5.0 mmol), CuI (0.0190 g, 0.1 mmol, 2 mol%), and TEMPO (0.0156 g, 0.1 mmol, 2 mol%) was directly stirred in open air at room temperature (ca. 30 oC) in a reaction tube. After completion of the reaction as monitored by GC-MS and/or TLC, the mixture was then directly purified, without any workup, through a Et3N-washed silica gel column using ethyl acetate and petroleum ether as the eluent, affording N-benzylidenebenzylamine 2a in 85% isolated yield.
According to the analysis of related databases, 4152-90-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Huang, Bo; Tian, Haiwen; Lin, Shoushuai; Xie, Meihua; Yu, Xiaochun; Xu, Qing; Tetrahedron Letters; vol. 54; 22; (2013); p. 2861 – 2864;,
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