Related Products of 6775-78-6, These common heterocyclic compound, 6775-78-6, name is 6-Chloroimidazo[1,2-b]pyridazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Stage 1.2: 3-Bromo-6-chloro-imidazo[1,2-b]pyridazine (II). 6-Chloro-imidazo[1,2-b]pyridazine (I) (example 1; stage 1.1) (4.94 g; 29.3 mMol) is dissolved in DMF (50 mL) and cooled to 0C. At this temperature, N-bromo-succinimide (5.76 g; 30.7 mMol) is added and the brown solution is stirred at OC for 2 h, followed by stirring at RT for 1h. The brown solution is taken up into EtOAc (400 mL) and washed with water (2x 200 mL), followed by back extraction of the aqueous layers with EtOAc (1x 200 mL). The combined organic layers are dried (Na2SO4), and concentrated under reduced pressure to obtain the title compound as yellowish crystals; mp. 132-137C; MS(ESI+):m/z= 233.8 (M+H)+; HPLC: tRet = 4.61 min (System 1). The title compound is used in the next step without further purification. Additional material can be isolated from the mother liquor. The structure is confirmed by x-ray analysis; it contains N-bromo-succinimide.
The synthetic route of 6775-78-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; WO2008/138889; (2008); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics