Reference of 461432-23-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 461432-23-5, name is 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene (4.9 g, 15 mmol) and 20 mL of tetrahydrofuran were added to a 50 mL three-necked flask, and the mixture was stirred and cooled to -5 to 0 C.Isopropylmagnesium chloride Grignard reagent (8 mL, 2 mol/L) was slowly added dropwise, and the system was stirred at 0 C for 2 h.In another 100mL three-neck bottle, add(2R,3R,4S,5R,6R)-2-bromo-6-(pivaloyloxymethyl)tetrahydro-2H-pyran-3,4,5-tripivalyl ester (IIb, 5.8 g , 10 mmol), tetramethylethylenediamine (5 wt%),Cobalt triacetylacetonate (5 wt%) and 20 mL of tetrahydrofuran were cooled to 0 C.Slowly add the Grignard reagent in the previous 50mL bottle and add it in about 30min.The system was warmed to 25-30 C, stirred under heat for 2 h, and the system was quenched with 1N aqueous hydrochloric acid.The organic phase was extracted with EtOAc, brine and brine.Column chromatography (PE/EA = 6/1) gave the target product (5.4 g, yield 72%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shanghai Fangnan Biological Technology Co., Ltd.; Zhang Nian; (6 pag.)CN104059041; (2018); B;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics