Related Products of 56961-77-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56961-77-4, name is 1-Bromo-2,3-dichlorobenzene belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Intermediate 1-1 was synthesized according to the following reaction formula. 3-chloro-10H-spiro(acridine-9,9′-fluorene) (27.4 mmol, 10 g) after dissolving in 100 mL of xylene, NatBuO (137 mmol, 13.2 g) was added and stirred at 180 C Then, 1-bromo-2,3-dichlorobenzene (9.16 mmol, 2.05 g) and BTP (0.36 mmol, 0.2 g) were added sequentially. After 12 hours, the reaction was quenched with a saturated aqueous solution of ammonium chloride and extracted with ethyl acetate and water.The impure target obtained by concentration under reduced pressure was purified by column chromatography using an ethyl acetate / normal nucleic acid solvent to obtain 2.5 g (33% yield) of Intermediate 1-1.
The synthetic route of 1-Bromo-2,3-dichlorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG Chem, Ltd.; Gu Gi-dong; Keum Su-jeong; Yoon Jeong-min; Kim Gong-gyeom; (50 pag.)KR2019/37176; (2019); A;,
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