Adding a certain compound to certain chemical reactions, such as: 622-86-6, name is (2-Chloroethoxy)benzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 622-86-6, name: (2-Chloroethoxy)benzene
A.27 Synthesis of [(PhOCH2CH2)2ImH]Cl (27) (2-chloroethoxy)benzene (5.02 g, 32.05 mmol) and l-(trimethylsilyl)imidazole (1.33 g, 9.48 mmol) and toluene (5 mL) were stirred at 1 10C for 7 days in complete darkness. The resultant biphasic mixture was cooled to room temperature and the top layer was discarded. The viscous bottom layer was dissolved in dichloromethane (1 mL) and pentane (50 mL) was added. The precipitated oil was washed with pentane (3×20 mL) and dried under high vacuum (3.27 g, quantitative). The product is an extremely viscous wax which solidifies completely over the course of several weeks. The following analytical data were obtained. *H NMR (CD2C12): delta 1 1.12 (s, 1H, NCHN), 7.57 (s, 2H, NCHCHN), 7.26 (t, 3JH-H= 7.7 Hz, 4H, m- CH), 6.97 (t, 4.8 Hz, 4H, 2xCH2), 4.39 (vt, 3JH-H= 4.8 Hz, 4H, 2xCH2). 13C NMR
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics