Related Products of 60811-18-9, These common heterocyclic compound, 60811-18-9, name is 4-Bromo-1-chloro-2-fluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-Bromo-4-chloro-3-fluorobenzene (1 g, 4.8 mmol), bis(pinacolato)diboron (1.33 g, 5.3 mmol), potassium acetate (1.4 g, 14.3 mmol) and bis(triphenylphosphine)palladium dichloride (0.2 g, 0.29 mmol) were suspended in dioxane (20 ml). The yellow suspension was flushed with argon for 30 minutes and refluxed for 12 hours. The reaction mixture was cooled to room temperature, diluted with ethyl acetate, washed with brine, dried over Na2SO4 and concentrated in vacuo. The residue was chromatographed over silica gel (hexane-ethyl acetate 99:1) to provide 2-(4-chloro-3-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (0.7 g, 59%) as a colorless oil, MS: m/e=256.2 (M+).
Statistics shows that 4-Bromo-1-chloro-2-fluorobenzene is playing an increasingly important role. we look forward to future research findings about 60811-18-9.
Reference:
Patent; Buettelmann, Bernd; Neidhart, Marie-Paule Heitz; Jaeschke, Georg; Pinard, Emmanuel; US2003/229096; (2003); A1;,
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