Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15205-11-5, name is 2-Chloro-4-fluorobenzylamine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-Chloro-4-fluorobenzylamine
A mixture of intermediate 59 (200 mg, 0.54 mmol), 2-chloro-4-fluorobenzylamine (0.5 mL, 3.76 mmol) is heated at 100 C. (reaction block) for 2 days. The reaction mixture is cooled to RT. The corresponding N-Boc intermediate is not isolated. The reaction mixture is dissolved in EtOAc (10 mL) and hydrogen chloride is bubbled into the solution for 1 min, and the solution is stirred at RT overnight. The reaction mixture is neutralized, the solvent is evaporated, and the residue is purified by chromatography on silica gel; gradient elution with heptane:EtOAc (70:30-50:50) gives 73 mg of the product 101. LC/MS: 1.78 min, m/z 380 (M++1).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15205-11-5.
Reference:
Patent; Aventis Pharmaceuticals Inc.; US2005/26916; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics