Reference of 1871-57-4,Some common heterocyclic compound, 1871-57-4, name is 3-Chloro-2-chloromethyl-1-propene, molecular formula is C4H6Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1.0kg 3-chloro-2-chloromethylprop-1-ene,37.6g pinacol and 28.6g dibenzo-18-crown-6 were dissolved in 4.2kg tribromomethane,At a temperature controlled at 18-25 degrees, dropwise add 3.2kg of sodium hydroxide and 460g of potassium bromide to dissolve in 3.2kg of aqueous solution.Reaction for 50 hours; after the reaction is complete, add water and toluene, filter through celite pad,Wash the filter cake, combine the filtrates, separate the liquid, collect the organic phase, and concentrate to a small volume,Add n-heptane to crystallize at 0 degree, filter,Drying gave 1.185kg 1,1-dibromo-2,2-bis(chloromethyl)cyclopropane, light yellow solid, yield 50%, HPLC purity 98.7%.
The synthetic route of 1871-57-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Aisite (Chengdu) Bio-pharmaceutical Co., Ltd.; Wang Yin; Ha Leikeruishennan·kelatuer·nalaximuhan·kunqitapadamu; La Gehaiwende·laao·moshala; Zhao Zhenyu; Xu Hui; Guo Peng; (9 pag.)CN110759840; (2020); A;,
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