Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 918538-05-3, name is 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine
Weigh the intermediate 1-e (50 mg, 0.27 mmol)1-methyl-1H-pyrazole-4-boronic acid pinacol ester (55 mg, 0.27 mmol)2N aqueous Na2CO3 solution (0.27 ml, 0.54 mmol)Bis (triphenylphosphine) palladium (II) chloride (19 mg, 0.027 mmol)Dioxane (5 ml) was added to the flask and heated to 70 C for 16 h.After stopping the reaction,To the reaction solution was added 100 ml of water,Stir,Ethyl acetate (20 ml * 4)Drying the ester layer with anhydrous sodium sulfate,Concentrated, separated by column chromatography (petroleum ether: ethyl acetate = 5: 1),A yellow solid (55 mg, 88%) was obtained.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 918538-05-3.
Reference:
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Xin Minxing; Wen Jun; Tu Chongxing; Liu Zhaoyu; Shen Han; Wang Mengyu; Zhao Xinge; (36 pag.)CN104003990; (2017); B;,
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