Reference of 2106-04-9,Some common heterocyclic compound, 2106-04-9, name is 3-Chloro-2-fluoroaniline, molecular formula is C6H5ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of substituted aniline (0.8 mmol), potassiumcarbonate (553 mg, 4 mmol), and potassium iodide(13 mg, 0.08 mmol) in acetone (12 ml) was sitrred at roomtemperature. To the suspension, a solution of compound9 (179 mg, 0.8 mmol) was added in acetone (6 ml) dropwise.The reaction was stirred for 8 h and monitored byTLC. Solvent was removed under vaccum, followed bythe addition of ethyl acetate (40 ml) and water (30 ml).The organic layer was washed with water (30 ml × 1) andbrine (30 ml × 1), dried with anhydrous sodium sulfate,filtered, and concentrated. The crude material wasabsorbed onto silica gel and purified using 90% of petroleumether in ethyl acetate to yield title compound 10.
The synthetic route of 2106-04-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Guo, Guangzhu; Liu, Jianzhen; Wang, Guanjie; Zhang, Daoguang; Lu, Jinjie; Zhao, Guisen; Anti-Cancer Drugs; vol. 27; 4; (2016); p. 278 – 285;,
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