Synthetic Route of 108-70-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 108-70-3 as follows.
1-Bromopropane (25 g, 0.20 mol) was added dropwise to a mixture of Mg (5.0 g, 0.21 mol) in diethyl ether (100 mL) at room temperature. The mixture was refluxed for 2 h and then cooled to room temperature. The new prepared Grignard reagent was then added to a mixture of 1,3,5-trichlorobenzene (10.4 g, 570 mmol) and Ni(dppe)Cl2 (75 mg, 0.14 mmol) in 100 mL of diethyl ether at room temperature. The mixture was stirred overnight and quenched by adding a saturated aqueous NH4Cl. The resulting mixture was extracted with ether, and washed with deionized water. The organic layer was separated and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was purified by flash chromatography to give 1,3,5-trialkylbenzene (9.75 g, 84%) as a colorless oil.
According to the analysis of related databases, 108-70-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Liu, Taoping; Zhao, Xiaoming; Shen, Qilong; Lu, Long; Tetrahedron; vol. 68; 32; (2012); p. 6535 – 6547;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics