Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6940-78-9, name is 1-Bromo-4-chlorobutane, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H8BrCl
31 g of NaH (1.292 mol) was dissolved in 140 ml of DMF in batches under nitrogen blanket and ice bath.Weigh out 3-methyl-6-azauracil 14g (0.110mol),Dissolved in DMF in batches,After stirring for 1 hour,Add 1-bromo-4-chlorobutane 20g,The reaction continued overnight at room temperature.The reaction mixture was then added to ice water and extracted twice with EA.The combined organic phases were washed with brine.It was dried over anhydrous sodium sulfate and concentrated.The residue was purified by silica gel column chromatography.Obtaining a solid product2-(4-Chlorobutyl)-4-methyl-1,2,4-triazin-3,5(2H,4H)-dione (CD-5)9g (0.041mol, yield: 72%)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Central South University; Zhong Shian; Peng Wei; Chen Jian; Liu Hui; Li Xiufang; Li Jianbing; Tang Rongdi; (16 pag.)CN108440505; (2018); A;,
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