Related Products of 452-83-5,Some common heterocyclic compound, 452-83-5, name is 2-Chloro-5-fluoroaniline, molecular formula is C6H5ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
a) 2-Chloro-5-fluorobenzenesulfonyl chloride 5 g (34.3 mM) of 2-chloro-5-fluoroaniline were slowly added to a solution of 17 ml of concentrated hydrochloric acid solution and 11 ml of water at 0 C. The reaction mixture is stirred at 0 C. for 1 hour. Addition of 2.49 g (36.1 mM) of NaNO2 in 6 ml of H2O is followed by stirring the mixture at 0 C. for 15 minutes and then adding to a solution of 692 mg (5.15 mM) of sulfur dioxide and copper(II) chloride in 10 ml of acetic acid. The reactants were stirred at 0 C. for 15 minutes and then at room temperature for a further 15 minutes. The reaction mixture is extracted with EtOAc. The organic phase is concentrated, dissolved in EtOAc, washed with 1N NaHCO3 solution, dried over MgSO4 and concentrated. 7.86 g of the desired sulfonyl chloride are obtained as a yellow oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-5-fluoroaniline, its application will become more common.
Reference:
Patent; SANOFI-AVENTIS DEUTSCHLAND GMBH; US2007/197539; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics