Related Products of 501-29-1, A common heterocyclic compound, 501-29-1, name is 1-Chloro-2-fluoro-4-methoxybenzene, molecular formula is C7H6ClFO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Example 16; 2-Bromo-4-chloro-5-fluoroaisole (Reference Compound No.16-1) A mixture of 4-chloro-3-fluoroanisole (124 muL, 1.00 mmol) and N-bromosuccinimide was dissolved in mixed solvent of anhydrous N,N-dimethylformamide (0.5 mL) and anhydrous dichloromethane (1 mL), and stirred at 40C for 3 days. After cooling down, chloroform (30 mL) and water (30 mL) were added and partitioned. The water layer was extracted with chloroform (30 mL, 2 times). The combined organic layer was washed with saturated brine (30 mL), dried over anhydrous magnesium sulfate, and then the solvent was removed under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane-ethyl acetate) to give the titled reference compound (195 mg) as a colorless solid. (Yield 82%)
The synthetic route of 501-29-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Santen Pharmaceutical Co., Ltd; EP1995242; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics