Related Products of 363-51-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 363-51-9 name is 2-Chloro-6-fluoroaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To 2-chloro-6-fluoroaniline (24.8 g, 165 mmol) in HOAc (90 mL) is added Ac2O (18 mL, 189 mmol) and the mixture is stirred at 90 C. for 1 h. After cooling to rt H2O is added and the mixture is neutralized with 2 M NaOH solution with stirring. The aqueous layer is extracted twice with DCM. The combined organic layer is washed with semi-saturated NaHCO3 solution and brine, dried over MgSO4 and evaporated to give the acetanilide which is used without further purification
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-6-fluoroaniline, and friends who are interested can also refer to it.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/322803; (2012); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics