1303587-99-6, name is 2-Chloro-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2-Chloro-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazine
Synthesis of 2-chloro-8-(4-fluorobenzyl)-7 , 8-dihydro-6H-pyrimido [5, 4-b] [I, 4] oxazine [0440] To a stirred solution of 2-chloro-7, 8-dihydro-6H-pyrimido [5, 4-b] [1, 4] oxazine (100 mg, 0.58 mmol) in DMF (1 mL) under argon atmosphere was added sodium hydride (27 mg, 1.16 mmol) at 0 C. After stirring for 10 mins, l-(bromomethyl)-4-fluorobenzene (132 mg, 0.70 mmol) was added at 0 C and stirred for 1 h. After consumption of the starting materials (monitored by TLC), the reaction was quenched with ice water (20 mL) and extracted with EtOAc (2 x 20 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to afford 2-chloro-8-(4-fluorobenzyl)-7, 8-dihydro- 6H-pyrimido [5, 4-b] [1, 4] oxazine (150 mg, 92%) as an off-white solid. 1H-NMR (DMSO- d6, 400 MHz): delta 7.70 (s, 1H), 7.36 (t, 2H), 7.18 (t, 2H), 4.75 (s, 2H), 4.19-4.16 (m, 2H), 3.51- 3.48 (m, 2H); LCMS: 279.9 (M+1); (column; X-Select CSH C-18 (50 3.0 mm, 3.5 mupiiota); RT 3.59 min 0.05% Aq TFA: ACN; 0.80 mL/min); TLC: 60% EtOAc/hexane (R 0.5).
The synthetic route of 1303587-99-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
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