Electric Literature of 16793-91-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16793-91-2, name is 2-Chlorophenethyl Bromide, This compound has unique chemical properties. The synthetic route is as follows.
Example 58 Preparation of 6-(2-chlorophenethyl)-1.2.3.4.5.6-hexahvdro-3.9- dimethylazepmor4.5-b1mdole (Compound No 69)[0423] The title compound was prepared by following general procedure 4 3,9-Dimethyl- l,2,3,4,5,6-hexahydroazepmo[4,5-b]mdole (214 mg, 1 0 mmol) was taken with copper iodide(19 mg, 0 1 mmol), L-pralme (23 mg, 0 2 mmol), potassium phosphate t?basic (426 mg, 2 0 mmol), l-(2-bromoethyl)-2-chlorobenzene (219 mg, 1 0 mmol) and DMF was added, the reaction was stirred at 900C under argon atmosphere for 12 h and monitored by LCMS After completion of the reaction water was added and extracted with ethyl acetate The organic layer was washed with water, dried over sodium sulfate and concentrated under vacuum The crude product was purified by reverse phase chromatography to afford 50 mg of the title compound (10 7%)
The chemical industry reduces the impact on the environment during synthesis 2-Chlorophenethyl Bromide. I believe this compound will play a more active role in future production and life.
Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; HUNG, David, T.; PROTTER, Andrew, Asher; JAIN, Rajendra, Parasmal; CHAKRAVARTY, Sarvajit; GIORGETTI, Marco; WO2010/51503; (2010); A1;,
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