Synthetic Route of 202197-26-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202197-26-0, name is 3-Chloro-4-((3-fluorobenzyl)oxy)aniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: A mixture of 14 (1.03 g, 5 mmol), 10 mL SOCl2 and five drops of DMF was stirred and refluxed for 6 h. Excess SOCl2 was removed under reduced pressure, gave the intermediate 15 without further purification. A mixture of intermediate 15 and aniline (5 mmol) dissolved in 15 mL isopropanol, 1 mL Et3N was added, the mixture was stirred at reflux for 4 h. the reaction mixture was allowed to cool to room temperature. The precipitate was collected and washed with isopropanol, water and ether in order, dried to provide the products 16a-c.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-4-((3-fluorobenzyl)oxy)aniline, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Li, Ri-Dong; Zhang, Xin; Li, Qiao-Yan; Ge, Ze-Mei; Li, Run-Tao; Bioorganic and Medicinal Chemistry Letters; vol. 21; 12; (2011); p. 3637 – 3640;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics