In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 67330-62-5 as follows. Quality Control of 3-Chloro-2,6-diethylaniline
A mixture of 7-hydroxynaphthalene- 1,3 -disulfonyl dichloride (255 mg, 0.75 mmol) and 2,6-diethylaniline (550 mg, 3.0 mmol) in acetonitrile (3 mL) was heated under reflux during 4 h. The reaction mixture was diluted with water (30 mL) and extracted with ethyl acetate (30 mL). The extract was washed with 4% HCl (30 mL), dried with Na2SO4, evaporated and purified by chromatography (petroleum ether- ethylacetate, 2:1). Yield 21 mg (4%), as a white powder, mp 142-144 C.1H NMR (DMSO-^), delta: 0.75-0.98 (m, 12H); 2.05-2.46 (m, 8H); 7.09 (dd, J = 8.4,2.1 Hz5 2H); 7.32 (d, J = 8.4 Hz5 2H); 7.38 (dd, J= 9.0, 2.2 Hz5 IH); 7.94 (d, J =2.2 Hz5 IH); 8.19 (d, J = 9.1 Hz, IH); 8.28 (d, J= 1.9 Hz, IH); 8.45 (d, J = 1.9 Hz, IH); 9.78 (s, IH); 10.01 (s, IH); 10.65 (s, IH).
According to the analysis of related databases, 67330-62-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BIOLIPOX AB; WO2007/42817; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics