In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2770-11-8 as follows. Recommanded Product: 2770-11-8
General Procedure for the Microwave-Assisted Preparation of the Final Piperidine Compounds.To a solution of 2-(4-chlorophenoxy)benzenamine (100 mg, 0.46 mmol), the relevant N-Acetyl-2-substituted-4-piperidone (0.92 mmol) and sodium triacetoxyborohydride (241 mg, 1.14 mmol) in DCE (1.5 ml) in a MW tube, was added acetic acid (83 mg, 1.38 mmol). The MW tube was sealed and heated at 14O0C for 10 rnins in a CEM discoverMW instrument. The reaction was quenched with a saturated aqueous solution of sodium bicarbonate (10 ml) and extracted with ethyl acetate (3 x 10 ml). The combined organics were dried (MgSO4), filtered and concentrated in vacuo. Purification by flash chromatography (eluant: hexane: ethyl acetate) then proceeded to provide the desired compound.l-(4-(2-(4-Chlorophenoxy)phenylamino)-2-phenylpiperidin-l-yl)ethanone STX2419C25H25ClN2O2, MoI. Wt.: 420.93Yellow oil, 41.3 mg, 21%1H NMR: (CDCl3, 270 MHz): delta 1.55-1.76 (2H, m, 2 x CH), 2.10 (1.5H, s, CH3), 2.23 (1.5H3 s, CH3), 2.69-2.82 (2H, m, CH), 3.12-3.22 (0.5H, m, CH)3 3.37-3.48 (0.5H5 m,CH), 3.52-3.62 (0.5H, m, CH), 3.75 (0.5H, ‘d’, J- 14.1 Hz, CH), 3.87-4.02 (0.5H, br S3CH), 4.74 (0.5H3 ‘d J = 13.9 Hz3 CH)3 5.17-5.23 (0.5H3 m, CH)3 6.13-6.14 (0.5H3 m, EPO
According to the analysis of related databases, 2770-11-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; STERIX LIMITED; WO2007/3934; (2007); A2;,
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