Some scientific research about

Adding a certain compound to certain chemical reactions, such as: 39226-95-4, name is 2,3-Dichlorobenzylamine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39226-95-4, Recommanded Product: 2,3-Dichlorobenzylamine

2-Bromo-4-(2,3-dichlorobenzylamino)-5-nitropyridine (2); [0087] To a solution of 2,4-dibromo-5-nitropyridine (1) (0.5 g, 1.77 mmol) in THF (10 mL) at 0 C was added a mixture of 2,3-dichlorobenzylamine (0.32 g, 1.82 mmol), diisopropylethylamine (0.62 mL, 3.56 mmol), and THF (10 mL) dropwise with stirring under argon. After addition, the resulting mixture was stirred at room temperature for 5 h when TLC analysis (EtOAc-hexanes, 1:4) showed that the reaction was complete. The mixture was then poured into cold water (60 mL) and extracted with DCM (2 x 60 mL). The combined organic layers were washed with brine, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by column chromatography (EtOAc-hexanes, 1 :6) to give 2 as a yellow solid (605 mg, 91%). LC-MS: Rt 7.72 min, m/e 378.0; 1H NMR (CDCl3) delta 9.00 (s, 1 H), 8.57 (s, broad, 1 H, NH), 7.48 (d, 1 H), 7.23 (d, 1 H), 7.18 (m, 1 H), 6.82 (s, 1 H), 4.61 (d, 2 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3-Dichlorobenzylamine, and friends who are interested can also refer to it.

Reference:
Patent; PHARMACOPEIA, INC.; WO2009/62059; (2009); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics