In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 932-96-7, name is 4-Chloro-N-methylaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 4-Chloro-N-methylaniline
General procedure: Under an argon atmosphere, a 3 mL vial was charged with 6b (5mol%), KOtBu (5 mol%) and CPME (2 mL). Substrate 8 (0.28 mmol,1 equiv.) and PhSiH3(3 equiv.) were added and the vial was sealed with a septum cap. The septum cap was pierced with a syringe needle and placed into a six-slot steal autoclave. The autoclave was sealed, purged twice with CO2 and heated at 100C (oil bath) under CO2 atmosphere (1 bar) for 20 h. After this time the reaction mixture was allowed to cool and the gas was carefully released. The reaction mixture was analyzed by gas chromatography (GC).
The synthetic route of 932-96-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Santoro, Orlando; Nahra, Fady; Cordes, David B.; Slawin, Alexandra M.Z.; Nolan, Steven P.; Cazin, Catherine S.J.; Journal of Molecular Catalysis A: Chemical; vol. 423; (2016); p. 85 – 91;,
Chloride – Wikipedia,
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