Synthetic Route of 210532-25-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 210532-25-5 as follows.
To a mixture of 3-({3-[(tetrahydro-pyran-4-yl)-(2,2,2-trifluoro-acetyl)-amino]-pyridine- 4-carbonyl}-amino)-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-l-carboxylic acid ethyl ester hydrochloride (0.75 mmol), dry dichloromethane (50 mL) and triethylamine (0.84 mL, 6 mmol) was added 3,5-difluorobenzenesulfonyl chloride (478 mg, 2.25 mmol). The mixture was stirred at room temperature for 4 hours then methanol (10 mL) and triethylamine (5 mL) were added. The mixture was then heated to 600C and the stirring continued for 2 hours. The solvents were evaporated and the crude residue purified by flash chromatography on silica gel, affording the title compound as pale yellow solid (100 mg). IH-NMR (400 MHz), delta (ppm, DMSOtZ6): 12.59, 12.35 (2s, IH), 11.04, 11.02 (2s, IH), 8.87, 8.82 (2s, IH), 7.93, 7.86 (2m, IH), 7.71-7.52 (m, 4H), 7.28 (d, IH), 4.61, 4.52 (2s, 2H), 3.86 (m, 2H), 3.81 (m, IH), 3.50 (m, 2H), 1.98 (m, 2H), 1.68, 1.64 (2s, 6H), 1.44 (m, 2H), mixture of tautomers
According to the analysis of related databases, 210532-25-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NERVIANO MEDICAL SCIENCES S.r.l.; WO2007/68637; (2007); A1;,
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