Synthetic Route of 367-22-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 367-22-6, name is 4-Chloro-3-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: The intermediate 4-ethoxy-1,3-benzenedisulfo chloride(1.2 g, 3.7 mmol) was dropwise added to a solution of 2,4-difluoro aniline (1.0 g, 7.5 mmol) with dichloromethane (15 mL) as solvent at room temperature under magneticstirring. After 10 min, triethylamine (0.5 mL) as acidbindingagent was dropwise added to the reaction mixture.The mixture was stirred under reflux at 35 C for about8 h. After the reaction completed as monitored by TLC, thesolvent was removed under reduced pressure. Under thecondition of ice bath, the mixture was dissolved in cold 5%NaOH aqueous solution to obtain filtrate. The solid wasobtained by adjusting the pH of filtrate with hydrochloricacid (VHCl: Vwater = 1:1) in the condition of ice salt bath.After filtrating and drying, crude product was prepared. Thecrude product was purified by recrystallization from ethanolwith excellent yield (Scheme 1).
The chemical industry reduces the impact on the environment during synthesis 4-Chloro-3-fluoroaniline. I believe this compound will play a more active role in future production and life.
Reference:
Article; Chen, Xin; Liu, Xiujie; Qiu, kai; Xu, Xiang; Li, Caiwen; Wang, Yan; Medicinal Chemistry Research; vol. 28; 9; (2019); p. 1388 – 1401;,
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