Synthetic Route of 139512-70-2, These common heterocyclic compound, 139512-70-2, name is 4-Chloro-5-fluorobenzene-1,2-diamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a mixture of compound 11 (0.46 mmol) and appropriate o-phenylenediamines (0.46 mmol) in ethanol was added a solution of Na2S2O5 (770 mg, 4 mmol) in H2O (1.6 mL). The resulting mixture was stirred at reflux for 4 h. after completion of reaction; the solution was evaporated under reduced pressure to remove ethanol, and partitioned between EtOAc and water. The organic layer was dried over Na2SO4, and concentrated in vacuo. The crude product was purified by column chromatography using EtOAc/hexane as eluant to afford pure compounds 12(a-l) in good yields.
The synthetic route of 139512-70-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kamal, Ahmed; Srinivasa Reddy; Polepalli, Sowjanya; Shalini, Nekkanti; Reddy, V. Ganga; Subba Rao; Jain, Nishant; Shankaraiah, Nagula; Bioorganic and Medicinal Chemistry; vol. 22; 19; (2014); p. 5466 – 5475;,
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