In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6940-78-9 as follows. Computed Properties of C4H8BrCl
Add potassium carbonate (9.42 g) in water (10ml) in round bottom flask and stirred for 10-15 min at 30-35C. To this add DMF (50ml) and 7-Hydroxy quinolin-2(lH)-one (10g), heated the resulting mixture to 35-40C and stirred for 10-15 min. To this added 1-Bromo-4-chloro butane (21.29 g) and stirred the reaction mass for 6-8 hours at 35-40C, added water (20ml) drop wise over a period of 30-40 minutes and stirred the reaction mass for 30-40 min at 35-40C. Cooled the reaction mass to 10C, filtered and washed with methanol (20 ml) and DM water (20 ml) at 25-30C to obtain wet material. Yield: 11.0 g, HPLC purity- 95.8%; Dimer Impurity: 1.49% To the resulting wet material (11.0 g), methanol (200ml) was added at 25-30C and heated to reflux till complete dissolution. To this added AMBER LITE IR 120 H (10g) at 65-70C and stirred for 1-1.5 hours at reflux temperature. Filtered the resulting mixture through hyflo at 60-65C and cooled the filtrate to 5-10C and stirred for 30 minutes. Filtered the material, washed with methanol (10 ml) and dried at 60-65C for 5-8 hours. Yield: 8.0 g, HPLC purity: 97.3%; Dimer impurity: 0.027%.
According to the analysis of related databases, 6940-78-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JUBILANT GENERICS LIMITED; BANSAL, Deepak; MISHRA, Himanchal; MISHRA, Vaibhav; SRIVASTAVA, Alka; VIR, Dharam; (24 pag.)WO2017/216661; (2017); A1;,
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