Adding a certain compound to certain chemical reactions, such as: 2106-02-7, name is 2-Chloro-4-fluoroaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2106-02-7, Application In Synthesis of 2-Chloro-4-fluoroaniline
DISSOLVE 1- (3, 5-BIS-TRIFLUOROMETHYL-BENZYL)-5-PHENYL-1H- [1, 2,3] triazole-4- carboxylic acid (398 mg, 0.96 mmol) in 1, 2-dichloromethane (2 mL) and DMF (2 drops) and add oxalyl chloride (0.083 mL, 0.96 mmol). After 1 h, concentrate the mixture under reduced pressure and dissolve the residue in pyridine (3 mL). Add 2-chloro-4- fluoroaniline (0.12 mL, 0.96 mmol) and DMAP (5 mg) and heat the mixture for 1 h at 100 C. Then cool the mixture to RT and concentrate under reduced pressure. Dissolve the residue in 20% IPROH/CHCL3 and wash with sat. aqueous NAHC03 and brine. Dry the organic layer over NA2SO4, filter and concentrate. Purify the residue by radial chromatography (MEOH/CHC13 gradient) to provide 93 mg (36%) of the title compound as a white foam. MS (ES) 543.0 (M+L) + ; RF= 0. 85 (2% MEOH/CHC13).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-4-fluoroaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/821; (2005); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics