Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7051-16-3, name is 1-Chloro-3,5-dimethoxybenzene, A new synthetic method of this compound is introduced below., Computed Properties of C8H9ClO2
General procedure: A 0.94 M soln of MeMgBr in THF (1.59 mL, 1.5 mmol) was added to a mixture of FeF3 (5.7 mg, 0.050 mmol) and 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride (64.4 mg, 0.15 mmol) in THF (2.0 mL) at 0C; 1-chloro-4-methoxybenzene (143 mg, 1.0 mmol) and undecane were then added at r.t. The mixture was stirred at 80 C for 24 h. The mixture was cooled to r.t. and an aliquot of the mixture was filtered through a Florisil pad. The product yield was determined by GC analysis (92% yield) using undecane as an internal standard. 1-Methoxy-4-methylbenzene is volatile, hence isolation was performed for the large-scale experiment using starting aryl chloride (5.6 mmol). The crude product was purified by column chromatography (silica gel, pentane, Rf = 0.06) and subsequent GPC to obtain the title compound (78.7 mg, 11%) as a colorless oil.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Agata, Ryosuke; Iwamoto, Takahiro; Nakagawa, Naohisa; Isozaki, Katsuhiro; Hatakeyama, Takuji; Takaya, Hikaru; Nakamura, Masaharu; Synthesis; vol. 47; 12; (2015); p. 1733 – 1740;,
Chloride – Wikipedia,
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