Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1996-30-1, name is 3-Bromo-4-fluorochlorobenzene, A new synthetic method of this compound is introduced below., SDS of cas: 1996-30-1
1 -(4-Chloro-2-(trimethylstannyl)phenyl)- 1 H- 1 ,2,4-triazole Step 1. 1 -(2-Bromo-4-chlorophenvD- 1 H- 1 ,2,4-triazole. To a mixture of 2-bromo-4-chloro-l- fluorobenzene (2 g, 9.6 mmol) and 4H-l ,2,4-triazole (0.79 g, 1 1.5 mmol) in DMF (20 mL) was added K2C03 (5.28 g, 38.2 mmol), and the mixture was stirred at 100C for 16 h. The mixture was diluted with water (50 mL) and extracted with EtOAc (50 mL x 3). The combined organic layers were dried over magnesium sulfate, filtered, and concentrated. The residue was purified by silica gel gradient chromatography (Si02, petroleum ether: EtOAc = 10: 1-1 : 1) to give the title compound. 1H NMR (CDC13, 400MHz): delta 8.48 (s, 1H), 8.14 (s, 1H), 7.77 (s, 1H), 7.46 (d, J=l . l Hz, 2H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Weiguo; EDMONDSON, Scott, D.; GUO, Zhuyan; MERTZ, Eric; OGAWA, Anthony, K.; SO, Sung-Sau; SUN, Wanying; BROCKUNIER, Linda, L.; ALI, Amjad; KUANG, Rongze; WU, Heping; WO2015/183709; (2015); A1;,
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