Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 60811-21-4, name is 4-Bromo-2-chloro-1-fluorobenzene, A new synthetic method of this compound is introduced below., Computed Properties of C6H3BrClF
4-Bromo-2-chloro-l-(2-cyano-2-methyl)ethylbenzeneTo a solution of the 4-bromo-2-chloro-l-fluorobenzene (2.1Og, 10.0 mmol) in toluene (15 mL) was added the isobutyronitrile (3.64 mL) followed by KHMDS (0.5 M solution in toluene, 15 mL, 7.50 mmol). Reaction heated at 60 0C for 10 mins and then cooled to 0 0C, poured into IM HCl (5 mL) and extracted with ethyl acetate (2 x 30 mL), orgs washed with brine (10 mL), dried over magnesium sulphate, filtered and concentrated in vacuo. Residue was purified by flash column chromatography (silica, 0 to 50 % EtOAc / hexanes) to yield a brown solid (970 mg, 38%). MS (+ve ESI) : Rt = 2.46 min, no mass ion (M+H)+ 1H NMR (400.132 MHz, CDC13) delta 1.85 (6H, s),7.35 (IH, d),7.43 (IH, m),7.61 (IH, d)
The synthetic route of 60811-21-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/1127; (2008); A1;,
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